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Its use for the treatment of addiction is usually strictly regulated. Infants born to mothers physically dependent on opioids may also be physically dependent and may exhibit respiratory difficulties and withdrawal symptoms (see PRECAUTIONS : Pregnancy, Labor and Delivery). If possible, use one pharmacy for all your prescriptions and over-the-counter products.

Marino is now three months clean, her eyes are clear, her fingernails have started to grow again and she has gained weight. Gender The use of methadone has not been evaluated for gender specificity.

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Many people receive this treatment through a methadone clinic or rehab facility. Palm Partners was founded in 1994 and was incorporated in Florida in the year 2003.At MethadoneClinic.com, we are here to provide you with high quality information related to the treatment of an opioid addiction through methadone. You can zoom in and out on the map by hovering your cursor over it and using the mouse wheel.

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Cytochrome P450 enzymes, primarily CYP3A4, CYP2B6, CYP2C19, and to a lesser extent CYP2C9 and CYP2D6, are responsible for conversion of methadone to EDDP and other inactive metabolites, which are excreted mainly in the urine. These are often localized in areas specifically in need of opioid addiction treatment options, especially bigger cities, but every state will allow you options to find the best, closest methadone treatment center. The drug, which had been developed a decade before by German scientists Max Bockmühl and Gustav Ehrhart, was lauded as an effective and less addictive substitute for painkillers like morphine and opiates. Always keep a current list of the drugs and supplements you take and review it with your healthcare providers and your pharmacist.

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Methadone also acted as a potent, noncompetitive α3β4 neuronal nicotinic acetylcholine receptor antagonist in rat receptors, expressed in human embryonic kidney cell lines.[45] [edit] Methadone has a slow metabolism and very high fat solubility, making it longer lasting than morphine-based drugs. Please don't take it before you know what your doing. Individuals and their families, in conjunction with their treatment teams, should then weigh the pros and cons of using methadone, and create a long-term treatment plan that accounts for all variables. Narcotics with mixed agonist-antagonist properties should not be used for pain control during labor in patients chronically treated with methadone as they may precipitate acute withdrawal. It's uncommon for tablets to be crushed and injected, but even the injectable solution can cause problems, especially if the same needle is used with multiple people or for multiple doses. Some people tolerate the medication very well and feel no appreciable side effects. Weight gain can also be a common side effect of methadone. Controversy[edit] Methadone substitution as a treatment of opioid addiction has been widely criticized in the social sciences for its role in social control of addicts.[79] It is suggested that methadone does not function as much to curb addiction as to redirect it and maintain dependency on authorised channels.

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