Effectiveness[edit] While methadone clinics are generally considered to be effective treatment options for patients addicted to opioids, especially when other interventions have failed, there is controversy surrounding the placement of methadone clinics. Read More » Selecting a Top Comprehensive Treatment Center Selecting a top methadone treatment clinic that best meets your specific needs is one of the most important steps on the path back from addiction. Carcinogenesis, Mutagenesis, Impairment Of Fertility Carcinogenesis The results of carcinogenicity assessment in B6C2F1 mice and Fischer 344 rats following dietary administration of two doses of methadone HCl have been published.
You should consult your physician or a nutritionist for more detailed information about adding a nutritional supplement to your diet. Avoid driving or operating machinery until you know how this medicine will affect you. The major hazards of methadone are respiratory depression and, to a lesser degree, systemic hypotension. Now you can automatically track services provided to each patient so non-allowed services won’t be performed, and stop out of compliance patients at the front desk before services are rendered.
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Call your treating physician and ask for guidance. Over time, dosage adjustments and the development of a tolerance to the medication tend to reduce the severity of experienced side effects.
Renal Impairment The use of methadone has not been extensively evaluated in patients with renal insufficiency. Monitoring: -Monitor closely for respiratory depression, especially within the first 24 to 72 hours of initiating therapy and following dose increases. -Monitor regularly for the development of addiction, abuse, and misuse. -Monitor for signs of hypotension upon initiating therapy and following dose increases, especially those whose blood pressure is compromised. -Monitor for signs and symptoms of QT prolongation, if used in at-risk patients or concomitantly with drugs that prolong the QT interval, consider monitoring ECG and electrolytes at baseline and periodically during treatment. -During the induction phase as patients are being withdrawn from illicit opioids, monitor of opioid withdrawal symptoms such as lacrimation, rhinorrhea, sneezing, yawning, excessive perspiration, goose-flesh, fever, chilling, irritability, weakness, anxiety, depression, dilated pupils, tremors, tachycardia, abdominal cramps, body aches, involuntary twitching, anorexia, nausea, vomiting, diarrhea, intestinal spasms. The dosage may need to be increased or the dosing interval decreased in pregnant patients receiving methadone. (See PRECAUTIONS : Pregnancy, Labor and Delivery, and DOSAGE AND ADMINISTRATION.) Renal Impairment Methadone pharmacokinetics have not been extensively evaluated in patients with renal insufficiency. Initial doses should be lower for patients whose tolerance is expected to be low at treatment entry. The withdrawal period can be much more prolonged than with other opioids, spanning anywhere from two weeks to several months. If you are referring to liquid methadone, 1 ml is equal to 10 mg.
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