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5 doctors agreed: Caution: Methadone in combination with Lorazepam can result in increased sedation. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Accidental or deliberate ingestion by a child may cause respiratory depression that can result in death. Methadone was first manufactured in the US by Eli Lilly, who obtained FDA approval on August 14, 1947, for their Dolophine 5 mg and 10 mg Tablets.

Methadone is affective when taken on once, twice, maybe 3 times a day, but no more than 30mg at a time,. Note: the oral solution should never be injected directly into the blood stream.

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The drug absorbs into the body slowly, offering pain relief while preventing the euphoric high characteristic of morphine. The physician must remember, however, that methadone is a longacting depressant (36 to 48 hours ), whereas opioid antagonists act for much shorter periods (one to three hours). Be sure your doctor knows if you also take stimulant medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting.

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In addition, methadone is used as part of a treatment program to help people who were addicted to opiate medications. Other side effects include weakness, headache, constipation, itching, and dry mouth. If a non-tolerant person takes a large dose of methadone, effective opioid antagonists are available to counteract the potentially lethal respiratory depression.

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Think twice before switching, if you want to be addicted worse then be my guest! There have been rare cases of sedation and respiratory depression in infants exposed to methadone through breast milk. This means you're more likely to have an accident as you cannot react as quickly as you should. Parenteral: -May be administered IV, IM or subcutaneously; IM or subcutaneous injections have not been well studied and absorption appears to be unpredictable; local tissue reactions may occur. The bar code system ensures integrity of the dispensing log. A heavy-handed culture at the Christchurch Methadone Programme (CMP) is condemning addicts to a world of suicide, accidental overdose, crime and prostitution, according to a damning review. The opioid conversions involving methadone or fentanyl are trickier than converting other opioids so I use an online calculator most of the time to do these conversions. In many parts of the United States, methadone clinics are few and far between, which presents problems for addicts seeking methadone treatment who live far from a clinic. The efforts of patients who are seeking rehabilitation, and clinic professionals who serve them, are significantly undermined by this criminal activity that surrounds them." [2] Relapse rates are high in patients who discontinue methadone maintenance, between 70-90%[3] The high relapse rate may be partially due to the severity of cases seen at methadone clinics, as well as the long-term effects of opioid use.

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