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Very dangerous if no opiate tolerance and a need for it! Methadone's peak respiratory depressant effects typically occur later, and persist longer than its peak analgesic effects. That coupled with the health problems associated with it and the lifestyle of being opiate dependant causes health problems that have to be dealt with.

Cytochrome P450 enzymes, primarily CYP3A4, CYP2B6, CYP2C19, and to a lesser extent CYP2C9 and CYP2D6, are responsible for conversion of methadone to EDDP and other inactive metabolites, which are excreted mainly in the urine. More info Methadone Clinic USA See more Methadone Clinic Thomasboro Illinois :: (877) 284-9698 - Methadone Clinic USA sites.google.com Methadone Clinic USA · 21 July 2016 · #MethadoneClinicUSA methadone_clinic_banner.png: Source: methadone_clinic_banner.png was… — Derek Littler (@methadoneUSA) July 21, 2016 Source: @methadoneUSA July 21, 2016 at 07:36PM...

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Your doctor or health care provider is best able to guide your treatment decisions based on your specific circumstances. In plasma, methadone is predominantly bound to α1 -acid glycoprotein (85% to 90%).

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A patient's prior analgesic treatment experience should be taken into account when dosing Methadone. Common methadone side effects may include: dizziness, drowsiness; nausea, vomiting; or increased sweating.

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Starting a patient on a relatively high dose of methadone or increasing the dosage too quickly can place the patient in jeopardy of accidental overdose. And honestly, if you are so uncomfortable during your methadone decrease, then you are probably going too fast or the doctor is decreasing you too fast. Take your time in this stage and consider the different facilities so that you know all of your options before you proceed. Marino has lived a hard life, but her withdrawal from methadone was "by far the most excruciating thing I have ever been through". "It was like I was in The Exorcist. Many other opioid drugs are far more deadly and dangerous than Methadone is, and that is why this drug is frequently used to wean people off of these other dangerous narcotics. While methadone is effective at managing cravings for other opioids, it can still be abused. Short-Term Side Effects Although carefully monitored dosages of methadone are legally and medically acceptable, methadone is still an opioid agonist drug like heroin or opium. Adverse effects include sedation, hypoventilation, constipation and miosis, in addition to tolerance, dependence and withdrawal difficulties.

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