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Dose adjustment should be cautious; deaths have occurred in early treatment due to the cumulative effects of the first several days' dosing. These drugs include diuretics, laxatives, and, in rare cases, mineralocorticoid hormones. Today, methadone is used both medically and illicitly.

Patients seeking to discontinue treatment with methadone for opioid dependence should be apprised of the high risk of relapse to illicit drug use associated with discontinuation of methadone maintenance treatment. These include: Abnormally low blood pressure Feeling faint Slow heartbeat Collapsed lung Decrease in lung function Fast heartbeat Trouble breathing Feeling of confusion If you are taking methadone and experiencing any side effects outside the norm, contact your medical professional immediately.

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Phenytoin In a pharmacokinetic study with patients on methadone maintenance therapy, phenytoin administration (250 mg b.i.d. initially for 1 day followed by 300 mg QD for 3 to 4 days) resulted in an approximately 50% reduction in methadone exposure and withdrawal symptoms occurred concurrently. They started him off on low doses and now he is up to 90. Sedation (drowsiness) People tend to experience drowsiness most severely during the first weeks of methadone maintenance treatment, and most people will develop a tolerance to the sedating effects of methadone a few weeks after dose stabilization.

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My question is, why is the 200 mil not holding me till the next mornings dose at this new clinic when at the old clinic the 120 mil held me till the next morning dose. Dealing with Side Effects Most people find the side effects of methadone quite manageable. Usually your system can eliminate the methadone within about 72 hours in most cases. Drug Interactions (see DRUG INTERACTIONS) Methadone undergoes hepatic N-demethylation by cytochrome P-450 isoforms, principally CYP3A4, CYP2B6, CYP2C19, and to a lesser extent by CYP2C9 and CYP2D6.

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This clinic locator will start by asking you in which state you want to search for methadone treatment. The principal therapeutic uses for methadone are analgesia and detoxification or maintenance treatment in opioid addiction. The focus of these clinics is the elimination or reduction of opioid usage by putting the patient on methadone which is a long acting opioid. Food and Drug Administration issued a Public Health Advisory about methadone titled "Methadone Use for Pain Control May Result in Death and Life-Threatening Changes in Breathing and Heart Beat". When the receptionist calls up patient histories, they are alerted if the patient is out of compliance. So, methadone can be used as a pain reliever and as part of drug addiction detoxification and maintenance programs.

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