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Too rapid titration for the patient's sensitivity is more likely to produce adverse effects. Adverse effects include sedation, hypoventilation, constipation and miosis, in addition to tolerance, dependence and withdrawal difficulties.

Other adverse reactions include the following: (listed alphabetically under each subsection) Body as a Whole: asthenia (weakness), edema, headache Cardiovascular:(also see WARNINGS: Cardiac Conduction Effects): arrhythmias, bigeminal rhythms, bradycardia, cardiomyopathy, ECG abnormalities, extrasystoles, flushing, heart failure, hypotension, palpitations, phlebitis, QT interval prolongation, syncope, T-wave inversion, tachycardia, torsade de pointes, ventricular fibrillation, ventricular tachycardia Digestive: abdominal pain, anorexia, biliary tract spasm, constipation, dry mouth, glossitis Hematologic and Lymphatic: reversible thrombocytopenia has been described in opioid addicts with chronic hepatitis Metabolic and Nutritional: hypokalemia, hypomagnesemia, weight gain Nervous: agitation, confusion, disorientation, dysphoria, euphoria, insomnia, seizures Respiratory: pulmonary edema, respiratory depression (see WARNINGS: Respiratory Depression) Skin and Appendages: pruritis, urticaria, other skin rashes, and rarely, hemorrhagic urticaria Special Senses: hallucinations, visual disturbances Urogenital: amenorrhea, antidiuretic effect, reduced libido and/or potency, urinary retention or hesitancy Maintenance on a Stabilized Dose During prolonged administration of methadone, as in a methadone maintenance treatment program, there is usually a gradual, yet progressive, disappearance of side effects over a period of several weeks. Mallinckrodt received approval for their branded generic, Methadose, on April 15, 1993 for their 5 mg and 10 mg Methadose Tablets.

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Regularly, it's used in detox settings for heroin users in order for them to accomplish a certain balance level and therefore be more open to longer-range treatment. Read more 8 8 Where can I find information on methadone withdrawal?

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Medication Guide PATIENT INFORMATION Patients should be cautioned that methadone, like all opioids, may impair the mental and/or physical abilities required for the performance of potentially hazardous tasks such as driving or operating machinery. Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea. Methadone may be habit-forming, even at regular doses. Other symptoms may also develop, including irritability, anxiety, backache, joint pain, weakness, abdominal cramps, insomnia, nausea, anorexia, vomiting, diarrhea, or increased blood pressure, respiratory rate, or heart rate. Tolerance and dependence[edit] As with other opioid medications, tolerance and dependence usually develop with repeated doses. Know your rights NEW CLAIMS Death row Scot Kenny Richey probed by cops after 'confessing' to killing toddler HEAT STREET Edinburgh pavement BUCKLES under heat as Scotland sizzles in Saharan heatwave TRAGIC Capital Scotland radio host shares heartbreaking tribute after partner's shock death NO FOX GIVEN Meet the assassins who earn hundreds a night shooting foxes in UK cities 'THANK YOU' Dying Rangers fan visited by heroes says it's 'nice way to end fantastic life' CRASH HORROR Up to 17 people 'seriously injured' after crash between lorry and bus on A47 IN THE DOCK Ex-STV and Radio Clyde host Bryce Curdy accused of raping 12-year-old in France In the show, which is due to be aired next year, a serial killer preys on mystical creatures in a dark futuristic city and the detective on the case becomes the prime suspect.

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Methadone-maintained patients beginning treatment with these antiretroviral drugs should be monitored for evidence of withdrawal effects and methadone dose should be adjusted accordingly. Read More You can google a narcotic conversion chart to see if the difference in dosage and medication is correct. Such opioid rotation is standard practice for managing people with tolerance development. Be sure your doctor knows if you also use: other narcotic medications - opioid pain medicine or prescription cough medicine; drugs that make you sleepy or slow your breathing - a sleeping pill, muscle relaxer, sedative, tranquilizer, or antipsychotic medicine; or drugs that affect serotonin levels in your body - medicine for depression, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. People taking methadone should contact their doctor if they: have difficulty breathing; become very drowsy and breathing slows down; have little movement of the chest with breathing; have a fast or slowed heartbeat; feel faint, extremely dizzy, confused, have irregular heartbeats or any other symptoms that are not typical. Read More » Selecting a Top Comprehensive Treatment Center Selecting a top methadone treatment clinic that best meets your specific needs is one of the most important steps on the path back from addiction. Read more 1 doctor agreed: 20 20 Today I was vomiting orange liquid with brown flecks in it.

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